Drniš is a relatively young settlement founded by the Turks in the 16th century, during their invasion into North Dalmatia. They founded the town due to the suitable position on the elevation above the west edge of Petrovo polje.
The inhabitants of Drniš have been traditionally engaged in agriculture, cattle-breeding and mining. The following economical activities are predominant in the border area of Drniš today: stone-cutting, production of lime and building material, the cultivation of vine and the production of quality wines, cattle-breeding, and the processing of famous Dalmatian ham from Drniš. The latter won many prizes.

The period of Turkish administration left visible traces in Drniš: two of five mosques are well preserved; and the remnants of an old Turkish fortress are still preserved on the site above the Čikola canyon.The Domicile Museum of the Drniš Area, opened in 1983 on the occasion of the hundredth anniversary of the birth of Ivan Meštrović, the great Croatian sculptor, is an important cultural building. "The Well of Life", a relief in marble by Ivan Meštrović, is located at the staircase of the town park. Accommodation is available in the hotel "Park" and in private family houses.